2 The Extrinsic Pathway of Apoptosis
نویسندگان
چکیده
Defects in the extrinsic pathway are linked to several disease states, including cancer. Pharmacologic manipulation of the extrinsic pathway holds exciting promise for cancer treatment. This review will discuss the current understanding of the molecular signaling events that originate from extracellular sources to initiate apoptosis, how the pathway is activated by conventional chemotherapeutic agents, and novel opportunities to exploit the extrinsic pathway for cancer treatments.
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